Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells

Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus purple artisan keycap membranaceus, have been extensively studied for their antitumor properties.In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells.The effects of APS and the anti-diabetic drug metformin on apoptosis and ferrop

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AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

Abstract Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis.Temozolomide is the only first-line drug for GBM.Unfortunately, the resistance issue is a classic problem.Therefore, it is essential to develop new drugs purple artisan keycap to treat GBM.As an oncogene, Skp2 is involved in the pathogenesis of various ca

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